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Skillet Blackened Catfish with Cajun-Spiced Roasted Vegetables

Name: Skillet Blackened Catfish with Cajun-Spiced Roasted Vegetables
Prep time: 15 min
Cook time: 20 min
Total time: 35 min
Yield: 4 servings
Cuisine: Cajun-American
Ingredients: 4 catfish fillets (about 6 oz each), skin removed; 2 teaspoons smoked paprika; 1 teaspoon onion powder; 1 teaspoon garlic powder; 1 teaspoon dried oregano; 1 teaspoon dried thyme; 1/2 teaspoon cayenne pepper; 1/2 teaspoon black pepper; 1 teaspoon salt; 2 tablespoons olive oil, divided; 1 medium red bell pepper, cut into strips; 1 medium green bell pepper, cut into strips; 1 medium yellow squash, sliced into 1/2-inch rounds; 1 cup cherry tomatoes, halved; 1 small red onion, sliced; 1 tablespoon lemon juice; Fresh parsley, chopped (for garnish)

By PanPotPlates Editorial TeamPublished Apr 29, 2026 | Updated May 12, 2026

Cajun-American 35 mins onepanskilletquickeasypescatarianlowcarbflavorfulweeknight

Skillet Blackened Catfish with Cajun-Spiced Roasted Vegetables with measured ingredients, 35-minute timing, 4-serving yield, and step-by-step instructions for one-pot, one-pan, skillet, casserole, and sheet-pan recipes.

Prep 15 min

Cook 20 min

Total 35 min

Servings 4

Difficulty easy

Cuisine Cajun-American

Ingredients

Servings 4

4 catfish fillets (about 6 oz each), skin removed
2 teaspoons smoked paprika
1 teaspoon onion powder
1 teaspoon garlic powder
1 teaspoon dried oregano
1 teaspoon dried thyme
1/2 teaspoon cayenne pepper
1/2 teaspoon black pepper
1 teaspoon salt
2 tablespoons olive oil, divided
1 medium red bell pepper, cut into strips
1 medium green bell pepper, cut into strips
1 medium yellow squash, sliced into 1/2-inch rounds
1 cup cherry tomatoes, halved
1 small red onion, sliced
1 tablespoon lemon juice
Fresh parsley, chopped (for garnish)

Ingredients for Skillet Blackened Catfish with Cajun-Spiced Roasted Vegetables

Instructions

Preheat oven to 425°F (220°C).
In a small bowl, mix smoked paprika, onion powder, garlic powder, oregano, thyme, cayenne pepper, black pepper, and salt to create the blackening seasoning.
Pat catfish fillets dry. Generously rub blackening seasoning on both sides of each fillet.
Heat 1 tablespoon olive oil in a large, oven-safe skillet over medium-high heat.
Sear the catfish fillets for 2-3 minutes per side until a dark crust forms. Remove and set aside.
Add the remaining 1 tablespoon olive oil to the skillet. Toss bell peppers, yellow squash, cherry tomatoes, and red onion with lemon juice, salt, and pepper, then add to skillet.
Spread vegetables evenly and roast in preheated oven for 10 minutes.
Remove skillet, place catfish fillets on vegetables, and return to oven for 5-7 minutes, or until fish flakes easily.
Garnish with fresh chopped parsley before serving.